Engineered Vascular Tissue Fabricated from Aggregated Smooth Muscle Cells
نویسندگان
چکیده
منابع مشابه
Engineered vascular tissue fabricated from aggregated smooth muscle cells.
The goal of this study was to develop a system to rapidly generate engineered tissue constructs from aggregated cells and cell-derived extracellular matrix (ECM) to enable evaluation of cell-derived tissue structure and function. Rat aortic smooth muscle cells seeded into annular agarose wells (2, 4 or 6 mm inside diameter) aggregated and formed thick tissue rings within 2 weeks of static cultu...
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There is an urgent need for an efficient approach to obtain a large-scale and renewable source of functional human vascular smooth muscle cells (VSMCs) to establish robust, patient-specific tissue model systems for studying the pathogenesis of vascular disease, and for developing novel therapeutic interventions. Here, we have derived a large quantity of highly enriched functional VSMCs from hum...
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Statement of Purpose: This study was focused on a collagen/cell mixture seeding method to improve the adhesion and proliferation of vascular smooth muscle cells (SMCs) in tubular porous scaffolds for vascular grafts application. Recently, poly(L-lactide-co-εcaprolactone) (PLCL) copolymers have been applied as a biomaterial for vascular graft due to the high elastic property. We previously repor...
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BACKGROUND Tissue factor (TF) is the main initiator of the arterial blood coagulation system, and aggregated LDL (agLDL) are found in the arterial intima. Our hypothesis is that agLDL internalization by vascular smooth muscle cells (VSMCs) may trigger TF-procoagulant activity. METHODS AND RESULTS Cultured human VSMCs were obtained from human coronary arteries of explanted hearts during transp...
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ژورنال
عنوان ژورنال: Cells Tissues Organs
سال: 2011
ISSN: 1422-6421,1422-6405
DOI: 10.1159/000322554